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Generic for ezetrol ) and a single dose of IV risedronate (60mg/kg) administered 3 hours after the other antiretroviral agents. This combination was initiated in a 1:1 ratio, with the high-dose treatment first. Seroconversions occurred in most patients and were usually complete within 6 to 8 weeks.
One hundred and fifty-eight participants (84%) received the high-dose treatment, and 58 (41%) took the high-dose and low-dose combination. Seroconversion rates (ie, when CD4 counts were >200 cells/mm3 and viral load <200 copies/mL) were 64% at baseline (low-dose treatment), 56% 6 months and high-dose treatment), 59% at 24 months (high-dose treatment). The time to first seroconversion was shorter (low-dose or high-dose treatment) than in the low-dose group (mean, 7.0 days; median, 5.4 and 9.9 days, respectively). The median time to first seroconversion in the high-dose group was 6.7 days, and generic drug for ezetrol in the high-dose low-dose groups, seroconversion occurred within 1 to 2 days.
Comment
The clinical results of a randomized, placebo-controlled trial in group of HIV-infected individuals are reported. We used a combination of three antiretroviral agents to produce a moderate response, with high rate of viral suppression, in patients with low CD4 counts and levels of HIV RNA >400 copies/mL. The low-dose and high-dose combinations were more effective at maintaining HIV viral suppression and preventing rebound in the first 6 months than was the low-dose group. Most patients maintained a durable viral suppression for at least 1 year. These results demonstrate that an HIV-specific antiviral regimen consisting of a combination two oral antiretrovirals and a single intravenous agent is feasible and acceptable.
A previous study of this design resulted in a reduction viral load of 56%, with the high-dose group showing greatest reduction (67%).29 In contrast, two recent randomized studies in HIV-infected individuals which three antiretroviral drugs Ezetrol $174 $79.5 – Per pill were combined showed reductions in viral load of 15.6% and 28%, respectively.30, 31 The authors of current trial reported that among the four groups (high-dose, low-dose, low-dose and high-dose groups), the median reduction in viral load was 30% the high-dose group; median reduction among the three groups of combination antiretrovirals was 50%.32, 33 A further limitation of the current study was that an HIV-specific antiviral regimen was used, unlike the combination of antiretrovirals used in our earlier studies. This was presumably a disadvantage because, as was the case in ezetrol price australia earlier studies, low-dose combination was associated with an increased risk of side effects.
A larger trial was planned for the United Kingdom, but study was terminated because of the lack a sufficient number of doses each antiretroviral agent for the low-dose combination, and because of the large difference in viral load among the groups. We were also unable to recruit adequate numbers of subjects who received multiple combinations of antiretrovirals because the potential for viral contamination. lack of adequate doses antiretrovirals suggests that the low-dose combination and high-dose may be feasible acceptable.
The present study showed that high-dose combination can be safely administered in HIV-infected individuals. Only one placebo-controlled trial has been conducted in patients with HIV which the combination was taken for 6 months to 1 year.25 In this study, the combination was administered orally, and the regimen consisted of all three antiretroviral agents. The HIV-specific efficacy of combination was moderate, occurring in 58% of subjects. The difference between efficacy rates in this study and those the previous HIV-specific drug trials is probably attributable to the use of a single oral agent in the present study and our earlier high-dose antiretroviral drug trial.
Our overall survival rate was very high (78%). This is in contrast to the failure of recent trials to demonstrate long-term virological suppression with combination antiretroviral therapy.17 We observed a survival benefit only among group of subjects who were in the initial phase of HIV progression, which means that the benefits observed were not due to initial viral suppression, since no virological benefit could be maintained. The survival benefit observed was comparable to that seen in previous studies of other antiretroviral drugs in combination with other antiretroviral drugs (eg, raltegravir).24, 25, 34
The use of a single antiretroviral agent was associated with certain.